extinction, in biology, the dying out or extermination of a species. Extinction occurs when species are diminished because of environmental forces (habitat fragmentation, global change, natural disaster, overexploitation of species for human use) or because of evolutionary changes in their members (genetic inbreeding, poor reproduction, decline in population numbers).

Rates of extinction vary widely. For example, during the last 100,000 years of the Pleistocene Epoch (about 2.6 million to 11,700 years ago), some 40 percent of the existing genera of large mammals in Africa and more than 70 percent in North America, South America, and Australia went extinct. Ecologists estimate that the present-day extinction rate is 1,000 to 10,000 times the background extinction rate (between one and five species per year) because of deforestation, habitat loss, overhunting, pollution, climate change, and other human activities—the sum total of which will likely result in the loss of between 30 and 50 percent of extant species by the middle of the 21st century.